Cancer cells are able to diffuse to other organs. Moreover, it is recently indicated that the diffusion capability of cancer cells is negatively correlated with their structure rigidity. Also, tumor growth is related to the normal function of newly-formed vessels. Enhancing the rigidity of cancer cells and increasing blood viscosity in tumor vessels are potential strategies for tumor treatment. The designed DNA origami monomer named “Nanoman” composes of an internal central axis and an external sliding tube that has a controllable linear motion. This monomer can be linked as polymer. As a result of external tube sliding, the polymer will transform between flexible and rigid status, making a remarkable change in the structural rigidity. Via transporting DNA origami polymer into the cell or vessels by certain method such as lipofection, it can adjust cell rigidity or viscosity in tumor vessels, which will offer a potential way for future tumor therapy.